{"id":32158,"date":"2024-10-24T15:20:40","date_gmt":"2024-10-24T13:20:40","guid":{"rendered":"https:\/\/carpem.fr\/?p=32158"},"modified":"2024-10-30T10:22:15","modified_gmt":"2024-10-30T09:22:15","slug":"labellisation_clipp_carpem_acti","status":"publish","type":"post","link":"https:\/\/carpem.fr\/en\/labellisation_clipp_carpem_acti\/","title":{"rendered":"CLIP\u00b2 Labeling of the University Hospital Group (GHU) APHP.centre-Universit\u00e9 Paris-Cit\u00e9, led by the Cancer Institute Paris CARPEM"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]The University Hospital Group (GHU) APHP.Centre &#8211; Universit\u00e9 Paris Cit\u00e9, led by the Cancer Institute Paris CARPEM, is honored to announce its recent CLIP\u00b2 (Early Phase Labeled Center) certification in adult oncology by the National Cancer Institute (INCa in French for Institut National du Cancer). The CLIP\u00b2 is named <strong>CARPEM-ACTI (Clinical Access to Innovative Therapeutics)<\/strong>.<\/p>\n<h1 class=\"styled-subtitle\"><strong><img class=\"size-medium wp-image-32187 aligncenter\" src=\"https:\/\/carpem.fr\/wp-content\/uploads\/2024\/10\/Capture-decran-2024-10-02-a-16.11.01-e1727878671581-300x128.png\" alt=\"\" width=\"300\" height=\"128\" srcset=\"https:\/\/carpem.fr\/wp-content\/uploads\/2024\/10\/Capture-decran-2024-10-02-a-16.11.01-e1727878671581-300x128.png 300w, https:\/\/carpem.fr\/wp-content\/uploads\/2024\/10\/Capture-decran-2024-10-02-a-16.11.01-e1727878671581-1024x435.png 1024w, https:\/\/carpem.fr\/wp-content\/uploads\/2024\/10\/Capture-decran-2024-10-02-a-16.11.01-e1727878671581-768x326.png 768w, https:\/\/carpem.fr\/wp-content\/uploads\/2024\/10\/Capture-decran-2024-10-02-a-16.11.01-e1727878671581.png 1494w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/strong><\/h1>\n<p>[\/vc_column_text][vc_btn title=&#8221;Visit the web site of CARPEM-ACTI&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css=&#8221;&#8221; link=&#8221;url:https%3A%2F%2Finstitutducancer-hopitauxcentre-u-paris.aphp.fr%2Fclip2-carpem-acti%2F|target:_blank&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_tta_accordion][vc_tta_section title=&#8221;What is a CLIP\u00b2?&#8221; tab_id=&#8221;1727949559256-b3c0345a-db0e&#8221;][vc_column_text css=&#8221;&#8221;]CLIP\u00b2 centers are research units located in healthcare institutions specializing in early-phase clinical research. The goals of this certification are <strong>to develop, structure, and increase the visibility of early-phase clinical research in France<\/strong>. The INCa (jointly with the French League Against Cancer for pediatric CLIP\u00b2 centers) provides logistical support to certified institutions to promote this aim and elevate the quality of early-phase clinical trials in France to the highest standards. <strong>CLIP\u00b2 centers design and conduct early-phase trials in accordance with patient protection rules and international regulations in the field<\/strong>. Among other commitments, they ensure that their clinical trial protocols and information <em>leaflets<\/em> are reviewed by patient committees prior to the initiation of trials.<\/p>\n<p><em><a href=\"https:\/\/www.e-cancer.fr\/Professionnels-de-la-recherche\/Recherche-clinique\/Structuration-de-la-recherche-clinique\/Les-CLIP2\">Learn more about CLIP\u00b2<\/a><\/em><\/p>\n<p><em><a href=\"https:\/\/www.e-cancer.fr\/Institut-national-du-cancer\/Appels-a-projets\/Appels-a-projets-resultats\/CLIPP2024\">The 16 centers CLIP\u00b2 certified from 2024 to 2029<\/a><\/em>[\/vc_column_text]<style>.thegem-custom-69d2b84a2e12419 .gem-icon  {font-size: 16px;}.thegem-custom-69d2b84a2e12419 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 24px; height: 24px; line-height: 24px;}.thegem-custom-69d2b84a2e12419 .gem-icon.gem-simple-icon {width: 16px; height: 16px; line-height: 16px;}.gem-infotext.thegem-custom-69d2b84a2e12419 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69d2b84a2e12419 .gem-infotext-icon {margin-right:8px !important;}<\/style><div class=\"gem-infotext alignment-left thegem-custom-69d2b84a2e12419\" style=\"\"> <div class=\"gem-infotext-wrap position--left vertical--center\"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-pack-thegemdemo gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\">&#xe92f;<\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\">&#xe92f;<\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize title-default\" style=\"\"> What is an early-phase clinical trial? What trials are conducted in the CARPEM-ACTI CLIP\u00b2? <\/div> <\/div> <div class=\"gem-infotext__description\"> <div class=\"description-customize text-body-tiny\" style=\"\"> Early-phase clinical trials are Phase I and I\/II trials. charge au CLIP\u00b2. The safety and efficacy levels of a new drug are determined during these initial phases. Multi-organ Phase II trials are also conducted at CLIP\u00b2. <\/div> <\/div> <\/div> <\/div> <\/div>[vc_column_text css=&#8221;&#8221;]<\/p>\n<div class=\"small-body\" style=\"text-align: left; padding-left: 40px;\"><em><a href=\"https:\/\/www.calameo.com\/read\/00181490519962d0e74ca\">Learn more about early-phase clinical trials (pages 5 et 6 from magazine Recherche Clinique C\u00f4t\u00e9 Patients de la Ligue Contre le Cancer)<\/a> <\/em><\/div>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;CLIP\u00b2 Organization&#8221; tab_id=&#8221;1727949559256-aa86077c-892e&#8221;][vc_column_text css=&#8221;&#8221;]The activities of CLIP\u00b2 CARPEM-ACTI are distributed across three sites of the GHU, responsible for the departments managing the tumors treated at CLIP\u00b2:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>The <a href=\"https:\/\/cancer-hopitalpompidou.aphp.fr\/recherches-et-innovations\/recherches-medicales-et-paramedicales\/\">CEPEC (Early-Phase Cancer Trial Center, Centre d&#8217;Essais Pr\u00e9coces en Canc\u00e9rologie in french)<\/a> at the European Hospital Georges Pompidou (referent: Dr Jacques MEDIONI):\n<ul>\n<li>Medical oncology<\/li>\n<li>Thoracic oncology, Head and neck oncology<\/li>\n<\/ul>\n<\/li>\n<li>The Clinical Reasearch Unit of Cochin Hospital (CCH) (referent: Pr J\u00e9r\u00f4me ALEXANDRE)\n<ul>\n<li>Medical oncology<\/li>\n<li>Thoracic oncology, Head and neck oncology<\/li>\n<li>Endocrinology and Dermatology<\/li>\n<\/ul>\n<\/li>\n<li>The <a href=\"https:\/\/hopital-necker.aphp.fr\/hematologie-adulte#1514652293219-5e17f863-92d509a9-25376607-6c59\">Adult hematology department of Necker Hospital<\/a> (NCK) (referent: Dr Laurent FRENZEL)\n<ul>\n<li>Medical oncology<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>CARPEM-ACTI activity is coordinated by Dr. Jacques MEDIONI (HEGP), assisted by co-directors: Prof. J\u00e9r\u00f4me ALEXANDRE (CCH), Dr Laurent FRENZEL (NCK) and Prof. Olivier HERMINE (NCK).[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Objectives of the CLIP\u00b2&#8221; tab_id=&#8221;1727949646412-4a863df4-3050&#8243;][vc_column_text css=&#8221;&#8221;]The leadership of the triumvirate of directors of CLIP\u00b2 aims to foster a culture of innovation and interdisciplinary collaboration, from basic science to patient care and vice versa. The scientific project CLIP\u00b2 CARPEM-ACTI is integrated into the scientific program of the Cancer Institute Paris CARPEM and aims <strong>to provide rapid access to new treatments for solid and hematological tumors<\/strong>. The clinical research project is structured into five main axes:[\/vc_column_text][vc_toggle title=&#8221;Axis 1 : First-in-Human trials&#8221; css=&#8221;&#8221;]Referents : Dr J Medioni (HEGP), Dr L Frenzel and Pr O Hermine (NCK)<\/p>\n<p>First-in-Man (FIM) axis corresponds to the expertise necessary to conduct trials involving the first exposure of a cancer patient to experimental drugs. These studies typically include a limited number of patients, with particular attention paid to safety and pharmacovigilance issues. Following the approval to conduct FIM trials in 2015 and an audit in 2023, CEPEC (main CLIP\u00b2 site) has conducted five FIM clinical trials in the past three years. The NCK site has also been authorized to conduct FIM studies for over 10 years, and this authorization was renewed in October 2022.[\/vc_toggle][vc_toggle title=&#8221;Axis 2 : Immune Checkpoints Inhibitors&#8221; css=&#8221;&#8221;]Referents : Pr S Oudard (HEGP), Pr E Tartour (HEGP)<\/p>\n<p>Immune checkpoint inhibitors axis encompasses early trials focused on drugs that act on the immune system to treat cancer patients. It is particularly active, especially in treating tumors eligible for immunotherapy usually managed at the Cancer Institute Paris CARPEM (kidney and lung cancers), as well as hematological malignancies like EBV-related tumors. This axis particularly benefits from the GHU&#8217;s expertise in immune biological monitoring and oncology specialties, as these therapies can induce side effects in multiple organs.[\/vc_toggle][vc_toggle title=&#8221;Axis 3 : Vectorized Internal Radiotherapy&#8221; css=&#8221;&#8221;]Referent : Pr J Clerc (CCH)<\/p>\n<p>Vectorized Internal Radiotherapy axis is implicated in various projects with new specific tracers against cancer. Here are examples of developed projects:<\/p>\n<ul>\n<li>Studies on PSMA_177Lu therapy, promoted by the industry for prostate cancers.<\/li>\n<li>An industrial study on CXCR4_68Ga as a diagnostic tracer in hematology (lymphomas).<\/li>\n<li>An academic study on CXCR4_68Ga in adrenal adenomas.<\/li>\n<li>An academic project in collaboration with CEA on the development of a new metabolic tracer using a fluorinated derivative of glutamine.<\/li>\n<li>A synthesis project on PSMA-177Lu for pre-therapeutic dosimetry to monitor high activity doses and complement external radiotherapy.<\/li>\n<\/ul>\n<p>[\/vc_toggle][vc_toggle title=&#8221;Axis 4 : Targeted molecular therapies&#8221; css=&#8221;&#8221;]Referents : Pr J Alexandre (CCH), Pr H Blons (HEGP)<\/p>\n<p>Cet axe se concentre les essais \u00e9tudiant de nouveaux compos\u00e9s qui ciblent les voies mol\u00e9culaires pathologiques impliqu\u00e9es dans le d\u00e9veloppement ou la progression du cancer. Pour recruter les patients de fa\u00e7on optimale, le CLIP<sup>2<\/sup> b\u00e9n\u00e9ficie des r\u00e9sultats du s\u00e9quen\u00e7age extensif (s\u00e9quen\u00e7age du g\u00e9nome entier et s\u00e9quen\u00e7age du transcriptome) r\u00e9alis\u00e9 sur la plateforme de g\u00e9nomique de l\u2019APHP-Centre et au sein du SIRIC CARPEM, et avec les r\u00e9unions multidisciplinaires des tumeurs mol\u00e9culaires de SeqOIA. La plateforme CARPEM (mise en place par l\u2019Institut du Cancer Paris CARPEM) a une activit\u00e9 de diagnostic somatique (caract\u00e9risation des tumeurs) et de pr\u00e9disposition aux cancers.<\/p>\n<p>This axis focuses on trials studying new compounds that target the pathological molecular pathways involved in cancer development or progression. To optimally recruit patients, CLIP\u00b2 benefits from extensive sequencing results (whole genome sequencing and transcriptome sequencing) carried out on the genomic platform of APHP-Centre and within the SIRIC CARPEM, along with multidisciplinary meetings for molecular tumor discussions at SeqOIA. The CARPEM platform (established by the Cancer Institute Paris CARPEM) has a somatic diagnosis activity (tumor characterization) and cancer predisposition assessment.[\/vc_toggle][vc_toggle title=&#8221;Axis 5 : Interventional radiology&#8221; css=&#8221;&#8221;]Referents : Pr O Pellerin (HEGP), Pr J- M Correas (NCK), Pr A Dohan (CCH)<\/p>\n<p>The early-phase research program of this axis will cover four main aspects of interventional radiology:<\/p>\n<ul>\n<li>Delivery of therapeutic compounds (drugs, radioactive elements, MTIs, or implantable smart medical devices, whether through intra-arterial or percutaneous injection)<\/li>\n<li>Evaluation of combination therapies involving ablation and intravenous\/intra-arterial chemotherapy<\/li>\n<li>Implementation of robotics in interventional radiology<\/li>\n<li>Development of a method for controlling analgesia through endovascular denervation<\/li>\n<\/ul>\n<p>[\/vc_toggle][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]The University Hospital Group (GHU) APHP.Centre &#8211; Universit\u00e9 Paris Cit\u00e9,&#8230;<\/p>\n","protected":false},"author":5,"featured_media":32164,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[318],"tags":[],"class_list":{"0":"post-32158","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-latest-news"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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