The present research program will explore epidemiological relationships between major signs of aberrant metabolism (overweight, obesity, vitamin deficiencies, metabolic syndrome, diabetes…) to the incidence, molecular subtype, outcome and therapeutic response of several major cancers, while focusing on mammary carcinoma, colorectal cancer, non-small-cell lung cancer and hepatocellular carcinoma). Such epidemiological links will be hypothesis-generating to investigate the possible cause-effect relationship between metabolic alterations at the whole-body level and cancer development in suitable mouse models and to perform interventional clinical trials (diet + exercise + treatment of obesity-related co-morbidities) on cancer patients