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Scientific activities

Scientific activities

Research institutions

The CARPEM program focuses on cross-disciplinary research leading to the development of personalized medicine.

The research teams associated with the present CARPEM project are working in the most prestigious Parisian research centers under the supervision of the Paris Descartes University:

TEAM 1: Pr Pierre Laurent-Puig
TEAM 15: Pr Marie-France Mamzer

TEAM 18: Pr Philippe Ravaud
TEAM 19: Dr Mathilde Touvier

TEAM 14: Pr Elizabeth Macintyre
                / Pr Olivier Hermine

TEAM 2: Pr Jessica Zucman-Rossi
TEAM 6: Pr Jérôme Galon
TEAM 7: Pr Guido Kroemer
TEAM 8: Pr Isabelle Cremer
TEAM 17: Dr Chantal Desdouets
TEAM 20: Pr Anita Burgun
TEAM 21: Dr Fabienne Foufelle
TEAM 22: Dr Sabine Colnot

TEAM 9: Pr Jérôme Bertherat
TEAM 10: Pr Frédéric Batteux
TEAM 11: Pr Didier Bouscary / Pr Michaëla Fontenay
TEAM 12: Dr Béatrice Romagnolo
TEAM 13: Dr Emmanuel Donnadieu
TEAM 16: Dr Valentina Boeva
TEAM 23: Dr Eric Pasmant

TEAM 3: Pr Anne-Paule Gimenez-Roqueplo
              / Dr Judith Favier
TEAM 4: Pr Eric Tartour
TEAM 5: Pr Olivier Clément / Pr Bertrand Tavitian

Team 1 : Personalized Medicine, Pharmacogenomics and Therapeutic Optimization (MEPPOT)

Centre Universitaire des Saints-Pères
Pr Pierre Laurent-Puig

Last publication :
Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.
There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this phenotype in stage III colon cancer characterized for mismatch repair (MMR), RAS, and BRAF status, and treated with adjuvant FOLFOX-based regimen…
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Team 2 : Functional genomics of solid tumors

Cordeliers Research Center
Pr Jessica Zucman-Rossi

Last publication :
Adeno-associated virus in the liver: natural history and consequences in tumour development.
Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV infection in the liver and its consequence in tumour development.…
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Team 3 : Genetics and Metabolism of Rare Cancers

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Anne-Paule Gimenez-Roqueplo and Dr Judith Favier

Last publication :
Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. Whereas most PPGLs are benign, up to 20% may become metastatic with SDHB- and FH-mutated tumors showing the higher risk. We aimed at determining the contribution of immortalization mechanisms to metastatic progression.
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Team 4 : Immunotherapy and antiangiogenic therapy in oncology

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Eric Tartour

Last publication :
HPV RNA CISH score identifies two prognostic groups in a p16 positive oropharyngeal squamous cell carcinoma population.
HPV-related and HPV-unrelated oropharyngeal squamous cell carcinomas are two distinct entities according to the Union for International Cancer Control, with a better prognosis conferred to HPV-related oropharyngeal squamous cell carcinomas. However, variable clinical outcomes are observed among patients with p16 positive…
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Team 5 : In vivo Imaging Research

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Bertrand Tavitian

Last publication :
Performance evaluation of the PET component of a hybrid PET/CT-ultrafast ultrasound imaging instrument.
We recently introduced a hybrid imaging instrument, PETRUS, based on a combination of positron emission tomography (PET) for molecular imaging, x-ray computed tomography (CT) for anatomical imaging, co-registration and attenuation correction, and ultrafast ultrasound imaging (UUI) for motion-correction…
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Team 6 : Integrative Cancer Immunology

Cordeliers Research Center
Dr Jérôme Galon

  • Laboratory : Integrative Cancer Immunology.
  • Website
  • Affiliations : Centre de Recherche des Cordeliers, Université Paris 5, Inserm U1138
  • Address : 15 Rue de l’École de Médecine 75006 Paris
  • Contact : jerome.galon@crc.jussieu.fr
Last publication :
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had…
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Team 7 : Metabolism, Cancer & Immunity

Cordeliers Research Center
Pr Guido Kroemer

Last publication :
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial…
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Team 8 : Cancer, Immune Control and Escape

Cordeliers Research Center
Pr Isabelle Cremer

Last publication :
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma…
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Team 9 : Endocrine tumors and signaling

Institut Cochin
Pr Jérôme Bertherat

Last publication :
Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.
Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate…
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Team 10 : Oxidative stress, inflammation and cellular proliferation

Institut Cochin
Pr Frédéric Batteux

Last publication :
Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth.
The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by peripheral neuropathy …
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Team 11 : Normal and Pathological Hematopoiesis

Institut Cochin
Pr Didier Bouscary and Pr Michaëla Fontenay

Last publication :
T-cell large granular lymphocyte leukemia transformation into aggressive T-cell lymphoma: a report of two cases with molecular characterization.

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Team 12 : Intestinal Self-Renewal and Tumorigenesis

Institut Cochin
Dr Béatrice Romagnolo and Dr Christine Perret

Last publication :
LKB1 signaling is activated in CTNNB1-mutated HCC and positively regulates β-catenin-dependent CTNNB1-mutated HCC.
Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β-catenin (CTNNB1-mutated HCC), constitute a very homogeneous group. We previously characterized a distinctive metabolic…
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Team 13 : Cancer and Immune Response

Institut Cochin
Dr Emmanuel Donnadieu

Last publication :
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T cells from tumor islets is correlated …
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Team 14: Hematology and Pathology

Necker-Enfants Malades Institute (INEM)
Pr Elizabeth Macintyre and Pr Vahid Asnafi

  • Laboratory: Normal and pathological lymphoïd differenciation
  • Website
  • Affiliations: Necker-Enfants Malades Institute, UMRS 1151
  • Address: 156 rue de Vaugirard, 75015 Paris
  • Contact: elizabeth.macintyre@aphp.fr

Last publication:
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL.
Biological explanations for discrepancies in patients related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1 or TLX3 deregulated T-ALLs (TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic…
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Imagine Institute
Pr Olivier Hermine

  • Laboratory: Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications
  • Website
  • Affiliations: Imagine Institute, UMR 1163
  • Address: 24, Boulevard de Montparnasse, 75015 PARIS
  • Contact: olivier.hermine@fondationimagine.org

Last publication:
Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS.
BACKGROUND: Patients with mast cell diseases may suffer from various distressing symptoms, which can be insufficiently controlled with available therapies, severely affecting their quality of life. There is a need for new and safe treatment options for these patients.
OBJECTIVES: We aimed to evaluate safety and efficacy of omalizumab …
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Team 15 : Medical Ethics

Centre Universitaire des Saints-Pères
Pr Marie-France Mamzer

Last publication :
How to strengthen the presence of patients in health technology assessments conducted by the health authorities.
The constant development of health technologies, combined with the increase in the cost of treatment, means that States must continually make choices about the introduction of new technologies into their healthcare system and how they are to be funded. In France, the systematic participation of patients in these processes is…
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Team 16 : Computational Epi-Genetics of cancer

Institut Cochin
Dr Valentina Boeva

Last publication :
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.
In cancer, clonal evolution is assessed based on information coming from single nucleotide variants and copy number alterations. Nonetheless, existing methods often fail to accurately combine information from both sources to truthfully reconstruct clonal populations in a given tumor sample or in a set of tumor samples…
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Team 17 : Proliferation, Stress and Liver Physiopathology

Cordeliers Research Center
Dr Chantal Desdouets

Last publication :
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma.
Leukocyte cell-derived chemotaxin-2 (LECT2) was originally identified as a hepatocyte-secreted chemokine-like factor and a positive target of β-catenin signaling. Here, we dissected out the mechanisms by which LECT2 modulates hepatocellular carcinoma (HCC) development using both HCC mouse models and human HCC…
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Team 18 : Methods of therapeutic evaluation of chronic diseases

CRESS
Pr Philippe Ravaud

  • Laboratory : Methods of therapeutic evaluation of chronic diseases
  • Website : https://clinicalepidemio.fr/
  • Affiliations : CRESS, Centre d’épidémiologie clinique Hôpital Hôtel-Dieu, INSERM UMR1153
  • Address : 1, place du parvis Notre-Dame, 75004 Paris
  • Contact : sec.epidemio.htd@aphp.fr
Last publication :
Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.
Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable…
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Team 19 : Nutritional epidemiology

CRESS
Dr Mathilde Touvier

Last publication :
Fasting and weight-loss restrictive diet practices among 2,700 cancer survivors: results from the NutriNet-Santé cohort.
Nutrition is often used by cancer survivors as a lever to take charge of their own health. However, some dietary behaviors are not currently recommended for patients without medical supervision. Our study aimed at evaluating weight-loss restrictive diets and fasting practices among cancer survivors of the…
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Team 20 : Information Sciences to support Personalized Medicine

Cordeliers Research Center
Pr Anita Burgun

Last publication :
What can millions of laboratory test results tell us about the temporal aspect of data quality? Study of data spanning 17 years in a clinical data warehouse.
OBJECTIVE: To identify common temporal evolution profiles in biological data and propose a semi-automated method to these patterns in a clinical data warehouse (CDW). MATERIALS AND METHODS:We leveraged the CDW of the European Hospital Georges Pompidou and tracked the evolution of 192…
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Team 21 : Metabolic Diseases, Diabetes and co-morbidities

Centre de recherche des Cordeliers
Dr Fabienne Foufelle

Last publication :
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study…
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Team 22 : Oncogenic funtions of beta-catenin signaling in the liver

Cordeliers Research Center
Dr Sabine Colnot

Last publication :
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
Hepatocellular carcinoma (HCC) is the most prevalent primary tumour of the liver. About a third of these tumours presents activating mutations of the β-catenin gene. The molecular pathogenesis of HCC has been elucidated, but mortality remains high, and new therapeutic approaches, including treatments based on microRNAs…
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Team 23 : Genomics and epigenetics of rare tumors

Institut Cochin
Dr Eric Pasmant

  • Laboratory : Genomics and epigenetics of rare tumors
  • Website :
  • Affiliations : Institut Cochin, Inserm U1016
  • Address : 22 Rue Mechain, 75014 Paris
  • Contact : 

Last publication :
BRCA2 Loss-of-Function and High Sensitivity to Cisplatin-Based Chemotherapy in a Patient With a Pleomorphic Soft Tissue Sarcoma: Effect of Genomic Medicine.
We report the case of a patient with a BRCA2 germline mutation who developed a localized pleomorphic soft tissue sarcoma of the leg with poor prognostic features. BRCA2 germline mutations were not previously reported to be associated with pleomorphic sarcoma. BRCA2 loss-of-heterozygosity was found in the tumor, resulting…
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Centre de Recherche des Cordeliers
15 rue de l’École de Médecine
Escalier A RDC
75006 Paris

Yannick Ladeiro, PhD
Secrétaire Général
yannick.ladeiro@carpem.fr

Sandrine Pham, PhD
Coordinatrice Scientifique
sandrine.pham@carpem.fr

Agnès Casi
Responsable administrative et budgétaire
agnes.casi@carpem.fr

contact@carpem.fr

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