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Activités scientifiques

Activités scientifiques

Institutions de recherche

Le programme CARPEM est articulé autour d’objectifs de recherche interdisciplinaires menant au développement d’une médecine personnalisée.

Les équipes de recherche du consortium CARPEM sont réparties dans les plus grands centres de recherche parisiens sous la tutelle de l’université Paris Descartes :

ÉQUIPE 18: Pr Philippe Ravaud
ÉQUIPE 19: Dr Mathilde Touvier

ÉQUIPE 1: Pr Pierre Laurent-Puig
ÉQUIPE 2 : Pr Jessica Zucman-Rossi
ÉQUIPE 6 : Pr Jérôme Galon
ÉQUIPE 7 : Pr Guido Kroemer
ÉQUIPE 8 : Pr Isabelle Cremer
ÉQUIPE 15: Pr Marie-France Mamzer
ÉQUIPE 17 : Dr Chantal Desdouets
ÉQUIPE 20 : Pr Anita Burgun
ÉQUIPE 21 : Dr Fabienne Foufelle
ÉQUIPE 22 : Dr Sabine Colnot

ÉQUIPE 9 : Pr Jérôme Bertherat
ÉQUIPE 10 : Pr Frédéric Batteux
ÉQUIPE 11 : Pr Didier Bouscary 
                    / Pr Michaëla Fontenay
ÉQUIPE 12 : Dr Béatrice Romagnolo
ÉQUIPE 13 : Dr Emmanuel Donnadieu
ÉQUIPE 16 : Dr Valentina Boeva
ÉQUIPE 23 : Dr Eric Pasmant

ÉQUIPE 3 : Pr Anne-Paule Gimenez-Roqueplo
                 / Dr Judith Favier
ÉQUIPE 4 : Pr Eric Tartour
ÉQUIPE 5 : Pr Olivier Clément / Pr Bertrand Tavitian

ÉQUIPE 14 : Pr Elizabeth Macintyre
                    / Pr Olivier Hermine

Equipe 1 : Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, (MEPPOT)

Centre Universitaire des Saints-Pères
Pr Pierre Laurent-Puig

Dernière publication :
Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.
There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this phenotype in stage III colon cancer characterized for mismatch repair (MMR), RAS, and BRAF status, and treated with adjuvant FOLFOX-based regimen…
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Equipe 2 : Génomique Fonctionnelle des Tumeurs Solides

Centre de recherche des Cordeliers
Pr Jessica Zucman-Rossi

Dernière publication :
BAP1 Mutations Define a Homogeneous Subgroup of Hepatocellular Carcinoma With Fibrolamellar-Like Features and Activated PKA.
DNAJB1-PRKACA fusion is a specific driver event in fibrolamellar carcinoma (FLC), a rare subtype of hepatocellular carcinoma (HCC) that occurs in adolescents and young adults. In older patients, molecular determinants of HCC with mixed histological features of HCC and FLC (mixed-FLC/HCC) remain to be discovered…
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Equipe 3 : Génétique et Métabolisme des Cancers Rares

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Anne-Paule Gimenez-Roqueplo et Dr Judith Favier

Dernière publication :
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypoxic and hypermethylator phenotypes. The mechanisms leading to DNA hypermethylation and its contribution to SDH-deficient cancers remain undemonstrated….
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Equipe 4 : Immunothérapie et traitement anti-angiogénique en cancérologie

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Eric Tartour

Dernière publication :
HPV RNA CISH score identifies two prognostic groups in a p16 positive oropharyngeal squamous cell carcinoma population.
HPV-related and HPV-unrelated oropharyngeal squamous cell carcinomas are two distinct entities according to the Union for International Cancer Control, with a better prognosis conferred to HPV-related oropharyngeal squamous cell carcinomas. However, variable clinical outcomes are observed among patients with p16 positive…
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Equipe 5 : Recherche en imageries du vivant

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Bertrand Tavitian

Dernière publication :
Performance evaluation of the PET component of a hybrid PET/CT-ultrafast ultrasound imaging instrument.
We recently introduced a hybrid imaging instrument, PETRUS, based on a combination of positron emission tomography (PET) for molecular imaging, x-ray computed tomography (CT) for anatomical imaging, co-registration and attenuation correction, and ultrafast ultrasound imaging (UUI) for motion-correction…
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Equipe 6 : Immunologie et Cancérologie Intégratives

Centre de recherche des Cordeliers
Dr Jérôme Galon

Dernière publication :
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had…
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Equipe 7 : Apoptose Cancer et Immunité

Centre de recherche des Cordeliers
Pr Guido Kroemer

  • Laboratoire : Apoptosis, Cancer & Immunity
  • Site internet : http://www.kroemerlab.com
  • Affiliations : Centre de Recherche des Cordeliers, Université Paris 5, Inserm U1138
  • Adresse : 15 Rue de l’École de Médecine, 75006 Paris
  • Contact : guido.kroemer@inserm.fr

Dernière publication :
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial…
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Equipe 8 : Micro-environnement immunitaire et cancer

Centre de recherche des Cordeliers
Pr Isabelle Cremer

Dernière publication :
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma…
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Equipe 9 : Génomique et Signalisation des Tumeurs Endocrines

Institut Cochin
Pr Jérôme Bertherat

Dernière publication :
Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.
Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate…
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Equipe 10 : Stress oxydant, prolifération cellulaire et inflammation

Institut Cochin
Pr Frédéric Batteux

Dernière publication :
Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth.
The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by peripheral neuropathy …
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Equipe 11 : Hématopoïèse normale et pathologique

Institut Cochin
Pr Didier Bouscary et Pr Michaëla Fontenay

Dernière publication :
Dyserythropoiesis evaluated by RED score and hepcidin/ferritin levels predicts response to erythropoietin in lower risk myelodysplastic syndromes.
Erythropoiesis-stimulating agents are generally the first line of treatment of anemia in lower risk myelodysplastic syndrome patients. We prospectively investigated the predictive value of somatic mutations, and biomarkers of ineffective erythropoiesis including flow cytometry RED score, serum GDF-15, and hepcidin levels. Inclusion…
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Equipe 12 : Oncogenèse des épithéliums digestifs

Institut Cochin
Dr Béatrice Romagnolo et Dr Christine Perret

Dernière publication :
LKB1 signaling is activated in CTNNB1-mutated HCC and positively regulates β-catenin-dependent CTNNB1-mutated HCC.
Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β-catenin (CTNNB1-mutated HCC), constitute a very homogeneous group. We previously characterized a distinctive metabolic…
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Equipe 13 : Dynamique des interactions lymphocytaire T

Institut Cochin
Dr Emmanuel Donnadieu

Dernière publication :
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T cells from tumor islets is correlated …
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Equipe 14 : Hématologie et Pathologie

Institut Necker Enfant Malade (INEM)
Pr Elizabeth Macintyre / Pr Vahid Asnafi

  • Laboratoire : Différentiation Lymphoïde Normale et Pathologique
  • Site internet
  • Affiliations : Institut Necker Enfants Malades, UMRS 1151
  • Adresse : 156 rue de Vaugirard, 75015 Paris
  • Contact : elizabeth.macintyre@aphp.fr

Dernière publication :
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL.
Biological explanations for discrepancies in patients related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1 or TLX3 deregulated T-ALLs (TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic…
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Institut Imagine
Pr Olivier Hermine

  • Laboratoire : Mécanismes moléculaires des troubles hématologiques et implications thérapeutiques
  • Site internet
  • Affiliations : Institut Imagine, UMR 1163
  • Adresse : 24, Boulevard de Montparnasse, 75015 PARIS
  • Contact : olivier.hermine@fondationimagine.org

Dernière publication :
Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS.
BACKGROUND: Patients with mast cell diseases may suffer from various distressing symptoms, which can be insufficiently controlled with available therapies, severely affecting their quality of life. There is a need for new and safe treatment options for these patients.
OBJECTIVES: We aimed to evaluate safety and efficacy of omalizumab …
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Equipe 15 : Ethique médicale

Centre Universitaire des Saints-Pères
Pr Marie-France Mamzer

Dernière publication :
Perceptions of artificial intelligence in healthcare: findings from a qualitative survey study among actors in France.
Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the actual impact. Thus, we aimed to obtain both an overview of how French health professionals perceive the arrival of AI in daily…
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Equipe 16 : (Epi-)génétique computationnelle du cancer

Institut Cochin
Dr Valentina Boeva

Dernière publication :
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.
In cancer, clonal evolution is assessed based on information coming from single nucleotide variants and copy number alterations. Nonetheless, existing methods often fail to accurately combine information from both sources to truthfully reconstruct clonal populations in a given tumor sample or in a set of tumor samples…
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Equipe 17 : Cycle cellulaire et physiopathologies hépatiques

Centre de recherche des Cordeliers
Dr Chantal Desdouets

Dernière publication :
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma.
Leukocyte cell-derived chemotaxin-2 (LECT2) was originally identified as a hepatocyte-secreted chemokine-like factor and a positive target of β-catenin signaling. Here, we dissected out the mechanisms by which LECT2 modulates hepatocellular carcinoma (HCC) development using both HCC mouse models and human HCC…
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Equipe 18 : Méthodes de l’évaluation thérapeutique des maladies chroniques

CRESS
Pr Philippe Ravaud

  • Laboratoire : Nutritional epidemiology
  • Site internet : https://clinicalepidemio.fr/
  • Affiliations : CRESS, Centre d’épidémiologie clinique Hôpital Hôtel-Dieu, INSERM UMR1153
  • Adresse : 1, place du parvis Notre-Dame, 75004 Paris
  • Contact : sec.epidemio.htd@aphp.fr

Dernière publication :
Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.
Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable…
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Equipe 19 : Epidémiologie nutritionnelle

CRESS
Dr Mathilde Touvier

Dernière publication :

CARPEM-LYNCH : un programme de recherche qui lie des données hospitalières aux données de la cohorte NutriNet-Santé pour tester le consentement dynamique.

Les innovations technologiques ont contribué à l’évolution rapide de la recherche translationnelle, permettant le partage de plus grandes quantités de données. Toutefois, les méthodes permettant d’impliquer les patients dans la recherche n’ont pas suivi l’évolution des capacités de recherche. …
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Equipe 20 : Science de l’information pour soutenir la médecine personnalisée

Centre de recherche des Cordeliers
Pr Anita Burgun

Dernière publication :
What can millions of laboratory test results tell us about the temporal aspect of data quality? Study of data spanning 17 years in a clinical data warehouse.
OBJECTIVE: To identify common temporal evolution profiles in biological data and propose a semi-automated method to these patterns in a clinical data warehouse (CDW). MATERIALS AND METHODS:We leveraged the CDW of the European Hospital Georges Pompidou and tracked the evolution of 192…
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Equipe 21 : Maladies métaboliques, diabète et comorbidité

Centre de recherche des Cordeliers
Dr Fabienne Foufelle

Dernière publication :
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study…
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Equipe 22 : Oncogenic funtions of beta-catenin signaling in the liver

Centre de recherche des Cordeliers
Dr Sabine Colnot

Dernière publication :
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
Hepatocellular carcinoma (HCC) is the most prevalent primary tumour of the liver. About a third of these tumours presents activating mutations of the β-catenin gene. The molecular pathogenesis of HCC has been elucidated, but mortality remains high, and new therapeutic approaches, including treatments based on microRNAs…
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Equipe 23 : Génomique et épigénétique des tumeurs rares

Institut Cochin
Dr Eric Pasmant

  • Laboratoire : Génomique et épigénétique des tumeurs rares
  • Site internet :
  • Affiliations : Institut Cochin, Inserm U1016
  • Adresse : 22 Rue Mechain, 75014 Paris
  • Contact :

Dernière publication :
BRCA2 Loss-of-Function and High Sensitivity to Cisplatin-Based Chemotherapy in a Patient With a Pleomorphic Soft Tissue Sarcoma: Effect of Genomic Medicine.
We report the case of a patient with a BRCA2 germline mutation who developed a localized pleomorphic soft tissue sarcoma of the leg with poor prognostic features. BRCA2 germline mutations were not previously reported to be associated with pleomorphic sarcoma. BRCA2 loss-of-heterozygosity was found in the tumor, resulting…
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Centre de Recherche des Cordeliers
15 rue de l’École de Médecine
Escalier A RDC
75006 Paris

Yannick Ladeiro, PhD
Secrétaire Général
yannick.ladeiro@carpem.fr

Sandrine Pham, PhD
Coordinatrice Scientifique
sandrine.pham@carpem.fr

Agnès Casi
Responsable administrative et budgétaire
agnes.casi@carpem.fr

contact@carpem.fr

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