TLS in the Era of Cancer Therapies” symposium
Wolf H Fridman, Catherine Sautès-Fridman and Anna Dimberg organize the “TLS in the
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The CARPEM program focuses on cross-disciplinary research leading to the development of personalized medicine.
The research teams associated with the present CARPEM project are working in the most prestigious Parisian research centers under the supervision of the Paris Descartes University:
Centre Universitaire des Saints-Pères
Pr Pierre Laurent-Puig
Last publication :
Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.
There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this phenotype in stage III colon cancer characterized for mismatch repair (MMR), RAS, and BRAF status, and treated with adjuvant FOLFOX-based regimen…
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Cordeliers Research Center
Pr Jessica Zucman-Rossi
Last publication :
Adeno-associated virus in the liver: natural history and consequences in tumour development.
Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV infection in the liver and its consequence in tumour development.…
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PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Anne-Paule Gimenez-Roqueplo and Dr Judith Favier
PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Eric Tartour
PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Bertrand Tavitian
Cordeliers Research Center
Dr Jérôme Galon
Cordeliers Research Center
Pr Guido Kroemer
Cordeliers Research Center
Pr Isabelle Cremer
Institut Cochin
Pr Jérôme Bertherat
Institut Cochin
Pr Frédéric Batteux
Institut Cochin
Pr Didier Bouscary and Pr Michaëla Fontenay
Last publication :
T-cell large granular lymphocyte leukemia transformation into aggressive T-cell lymphoma: a report of two cases with molecular characterization.
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Institut Cochin
Dr Béatrice Romagnolo and Dr Christine Perret
Institut Cochin
Dr Emmanuel Donnadieu
Necker-Enfants Malades Institute (INEM)
Pr Elizabeth Macintyre and Pr Vahid Asnafi
Last publication:
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL.
Biological explanations for discrepancies in patients related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1 or TLX3 deregulated T-ALLs (TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic…
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Imagine Institute
Pr Olivier Hermine
Last publication:
Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS.
BACKGROUND: Patients with mast cell diseases may suffer from various distressing symptoms, which can be insufficiently controlled with available therapies, severely affecting their quality of life. There is a need for new and safe treatment options for these patients.
OBJECTIVES: We aimed to evaluate safety and efficacy of omalizumab …
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Centre Universitaire des Saints-Pères
Pr Marie-France Mamzer
Institut Cochin
Dr Valentina Boeva
Last publication :
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.
In cancer, clonal evolution is assessed based on information coming from single nucleotide variants and copy number alterations. Nonetheless, existing methods often fail to accurately combine information from both sources to truthfully reconstruct clonal populations in a given tumor sample or in a set of tumor samples…
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Cordeliers Research Center
Dr Chantal Desdouets
CRESS
Pr Philippe Ravaud
CRESS
Dr Mathilde Touvier
Cordeliers Research Center
Pr Anita Burgun
Last publication :
What can millions of laboratory test results tell us about the temporal aspect of data quality? Study of data spanning 17 years in a clinical data warehouse.
OBJECTIVE: To identify common temporal evolution profiles in biological data and propose a semi-automated method to these patterns in a clinical data warehouse (CDW). MATERIALS AND METHODS:We leveraged the CDW of the European Hospital Georges Pompidou and tracked the evolution of 192…
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Centre de recherche des Cordeliers
Dr Fabienne Foufelle
Last publication :
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study…
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Cordeliers Research Center
Dr Sabine Colnot
Institut Cochin
Dr Eric Pasmant
Last publication :
BRCA2 Loss-of-Function and High Sensitivity to Cisplatin-Based Chemotherapy in a Patient With a Pleomorphic Soft Tissue Sarcoma: Effect of Genomic Medicine.
We report the case of a patient with a BRCA2 germline mutation who developed a localized pleomorphic soft tissue sarcoma of the leg with poor prognostic features. BRCA2 germline mutations were not previously reported to be associated with pleomorphic sarcoma. BRCA2 loss-of-heterozygosity was found in the tumor, resulting…
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Wolf H Fridman, Catherine Sautès-Fridman and Anna Dimberg organize the “TLS in the
This first edition, dedicated to digestive oncology, was organized by Pr Gérard Friedlander,
A Suicide Gene Therapy Combining the Improvement of Cyclophosphamide Tumor Cytotoxicity and the
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Centre Universitaire des Saints-Pères Etage 4 – Pièce 446B 45 rue des Saints-Pères -75006 Paris
Carina Binet : Secrétaire Général du CARPEM
Tél. : 01 76 53 43 85 – carina.binet@carpem.fr
Aurore Hattabi, PhD : Coordinatrice Scientifique du CARPEM
Tél : 01 76 53 43 85 – aurore.hattabi@carpem.fr