Activités scientifiques

Institutions de recherche

Le programme CARPEM est articulé autour d’objectifs de recherche interdisciplinaires menant au développement d’une médecine personnalisée.

Les équipes de recherche du consortium CARPEM sont réparties dans les plus grands centres de recherche parisiens sous la tutelle de l’université Paris Descartes :

Equipe 1 : Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, (MEPPOT)

Centre Universitaire des Saints-Pères
Pr Pierre Laurent-Puig

Dernière publication :
Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.
There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this phenotype in stage III colon cancer characterized for mismatch repair (MMR), RAS, and BRAF status, and treated with adjuvant FOLFOX-based regimen…
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Equipe 2 : Génomique Fonctionnelle des Tumeurs Solides

Centre de recherche des Cordeliers
Pr Jessica Zucman-Rossi

Dernière publication :
APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures.
Hepatoblastoma (HB) is the most common liver cancer in children. We aimed to characterize HB related to APC (Adenomatous Polyposis Coli) germline mutation (APC-HB). This French multicentric retrospective study included 12 APC-HB patients under 5 at diagnosis. Clinical features of APC-HB were compared to…
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Equipe 3 : Génétique et Métabolisme des Cancers Rares

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Anne-Paule Gimenez-Roqueplo et Dr Judith Favier

Dernière publication :
Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. Whereas most PPGLs are benign, up to 20% may become metastatic with SDHB- and FH-mutated tumors showing the higher risk. We aimed at determining the contribution of immortalization mechanisms to metastatic progression…
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Equipe 4 : Immunothérapie et traitement anti-angiogénique en cancérologie

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Eric Tartour

Dernière publication :
HPV RNA CISH score identifies two prognostic groups in a p16 positive oropharyngeal squamous cell carcinoma population.
HPV-related and HPV-unrelated oropharyngeal squamous cell carcinomas are two distinct entities according to the Union for International Cancer Control, with a better prognosis conferred to HPV-related oropharyngeal squamous cell carcinomas. However, variable clinical outcomes are observed among patients with p16 positive…
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Equipe 5 : Recherche en imageries du vivant

PARCC (Paris Centre de recherche Cardiovasculaire)
Pr Bertrand Tavitian

Dernière publication :
Performance evaluation of the PET component of a hybrid PET/CT-ultrafast ultrasound imaging instrument.
We recently introduced a hybrid imaging instrument, PETRUS, based on a combination of positron emission tomography (PET) for molecular imaging, x-ray computed tomography (CT) for anatomical imaging, co-registration and attenuation correction, and ultrafast ultrasound imaging (UUI) for motion-correction…
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Equipe 6 : Immunologie et Cancérologie Intégratives

Centre de recherche des Cordeliers
Dr Jérôme Galon

Dernière publication :
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had…
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Equipe 7 : Apoptose Cancer et Immunité

Centre de recherche des Cordeliers
Pr Guido Kroemer

  • Laboratoire : Apoptosis, Cancer & Immunity
  • Site internet : http://www.kroemerlab.com
  • Affiliations : Centre de Recherche des Cordeliers, Université Paris 5, Inserm U1138
  • Adresse : 15 Rue de l’École de Médecine, 75006 Paris
  • Contact : guido.kroemer@inserm.fr

Dernière publication :
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial…
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Equipe 8 : Micro-environnement immunitaire et cancer

Centre de recherche des Cordeliers
Pr Isabelle Cremer

Dernière publication :
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma…
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Equipe 9 : Génomique et Signalisation des Tumeurs Endocrines

Institut Cochin
Pr Jérôme Bertherat

Dernière publication :
Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.
Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate…
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Equipe 10 : Stress oxydant, prolifération cellulaire et inflammation

Institut Cochin
Pr Frédéric Batteux

Dernière publication :
Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth.
The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by peripheral neuropathy …
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Equipe 11 : Hématopoïèse normale et pathologique

Institut Cochin
Pr Didier Bouscary et Pr Michaëla Fontenay

Dernière publication :
Dyserythropoiesis evaluated by RED score and hepcidin/ferritin levels predicts response to erythropoietin in lower risk myelodysplastic syndromes.
Erythropoiesis-stimulating agents are generally the first line of treatment of anemia in lower risk myelodysplastic syndrome patients. We prospectively investigated the predictive value of somatic mutations, and biomarkers of ineffective erythropoiesis including flow cytometry RED score, serum GDF-15, and hepcidin levels. Inclusion…
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Equipe 12 : Oncogenèse des épithéliums digestifs

Institut Cochin
Dr Béatrice Romagnolo et Dr Christine Perret

Dernière publication :
LKB1 signaling is activated in CTNNB1-mutated HCC and positively regulates β-catenin-dependent CTNNB1-mutated HCC.
Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β-catenin (CTNNB1-mutated HCC), constitute a very homogeneous group. We previously characterized a distinctive metabolic…
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Equipe 13 : Dynamique des interactions lymphocytaire T

Institut Cochin
Dr Emmanuel Donnadieu

Dernière publication :
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T cells from tumor islets is correlated …
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Equipe 14 : Différentiation Lymphoïde Normale et Pathologique,

Necker
Pr Elizabeth Macintyre

Dernière publication :
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL.
Biological explanations for discrepancies in patients related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1 or TLX3 deregulated T-ALLs (TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic…
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Equipe 15 : Ethique médicale

Centre Universitaire des Saints-Pères
Pr Marie-France Mamzer

Dernière publication :
How to strengthen the presence of patients in health technology assessments conducted by the health authorities.
The constant development of health technologies, combined with the increase in the cost of treatment, means that States must continually make choices about the introduction of new technologies into their healthcare system and how they are to be funded. In France, the systematic participation of patients in these processes is…
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Equipe 16 : (Epi-)génétique computationnelle du cancer

Institut Cochin
Dr Valentina Boeva

Dernière publication :
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.
In cancer, clonal evolution is assessed based on information coming from single nucleotide variants and copy number alterations. Nonetheless, existing methods often fail to accurately combine information from both sources to truthfully reconstruct clonal populations in a given tumor sample or in a set of tumor samples…
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Equipe 17 : Cycle cellulaire et physiopathologies hépatiques

Centre de recherche des Cordeliers
Dr Chantal Desdouets

Dernière publication :
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma.
Leukocyte cell-derived chemotaxin-2 (LECT2) was originally identified as a hepatocyte-secreted chemokine-like factor and a positive target of β-catenin signaling. Here, we dissected out the mechanisms by which LECT2 modulates hepatocellular carcinoma (HCC) development using both HCC mouse models and human HCC…
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Equipe 18 : Méthodes de l’évaluation thérapeutique des maladies chroniques

CRESS
Pr Philippe Ravaud

  • Laboratoire : Nutritional epidemiology
  • Site internet : https://clinicalepidemio.fr/
  • Affiliations : CRESS, Centre d’épidémiologie clinique Hôpital Hôtel-Dieu, INSERM UMR1153
  • Adresse : 1, place du parvis Notre-Dame, 75004 Paris
  • Contact : sec.epidemio.htd@aphp.fr

Dernière publication :
Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.
Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable…
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Equipe 19 : Epidémiologie nutritionnelle

CRESS
Dr Mathilde Touvier

Dernière publication :
Fasting and weight-loss restrictive diet practices among 2,700 cancer survivors: results from the NutriNet-Santé cohort.
Nutrition is often used by cancer survivors as a lever to take charge of their own health. However, some dietary behaviors are not currently recommended for patients without medical supervision. Our study aimed at evaluating weight-loss restrictive diets and fasting practices among cancer survivors of the…
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Equipe 20 : Science de l’information pour soutenir la médecine personnalisée

Centre de recherche des Cordeliers
Pr Anita Burgun

Dernière publication :
What can millions of laboratory test results tell us about the temporal aspect of data quality? Study of data spanning 17 years in a clinical data warehouse.
OBJECTIVE: To identify common temporal evolution profiles in biological data and propose a semi-automated method to these patterns in a clinical data warehouse (CDW). MATERIALS AND METHODS:We leveraged the CDW of the European Hospital Georges Pompidou and tracked the evolution of 192…
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Equipe 21 : Maladies métaboliques, diabète et comorbidité

Centre de recherche des Cordeliers
Dr Fabienne Foufelle

Dernière publication :
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study…
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Equipe 22 : Oncogenic funtions of beta-catenin signaling in the liver

Centre de recherche des Cordeliers
Dr Sabine Colnot

Dernière publication :
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
Hepatocellular carcinoma (HCC) is the most prevalent primary tumour of the liver. About a third of these tumours presents activating mutations of the β-catenin gene. The molecular pathogenesis of HCC has been elucidated, but mortality remains high, and new therapeutic approaches, including treatments based on microRNAs…
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Equipe 23 : Génomique et épigénétique des tumeurs rares

Institut Cochin
Dr Eric Pasmant

  • Laboratoire : Génomique et épigénétique des tumeurs rares
  • Site internet :
  • Affiliations : Institut Cochin, Inserm U1016
  • Adresse : 22 Rue Mechain, 75014 Paris
  • Contact :

Dernière publication :
BRCA2 Loss-of-Function and High Sensitivity to Cisplatin-Based Chemotherapy in a Patient With a Pleomorphic Soft Tissue Sarcoma: Effect of Genomic Medicine.
We report the case of a patient with a BRCA2 germline mutation who developed a localized pleomorphic soft tissue sarcoma of the leg with poor prognostic features. BRCA2 germline mutations were not previously reported to be associated with pleomorphic sarcoma. BRCA2 loss-of-heterozygosity was found in the tumor, resulting…
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ACTUALITÉS

INFORMATIONS

Contactez-nous

Centre Universitaire des Saints-Pères Etage 4 – Pièce 446B 45 rue des Saints-Pères -75006 Paris

Carina Binet : Secrétaire Général du CARPEM
Tél. : 01 76 53 43 85 – carina.binet@carpem.fr

Aurore Hattabi, PhD : Coordinatrice Scientifique du CARPEM
Tél : 01 76 53 43 85 – aurore.hattabi@carpem.fr

contact@carpem.fr